Botanicals & Natural substances
Neumentix Spearmint Extract
Introduction to Mentha Spicata
Spearmint (Mentha spicata) is a herb rich in rosmarinic acid, carvone, and other polyphenols (natural compounds found in plants). Traditionally enjoyed for its wellness properties, research suggests its potential role in supporting cognitive health (1). Spearmint is associated with antioxidant activity and may support brain wellness and healthy aging (1, 2). Axolt has chosen Neumentix™ as a high-quality spearmint extract. Neumentix™ is derived from patented spearmint lines rich in polyphenols. It is designed to support mental clarity and focus without impacting sleep (3). Neumentix is a polyphenol-rich ingredient sourced from clonal spearmint lines developed for their high rosmarinic acid content, containing over 50 diverse polyphenols, including salvianolic acid, lithospermic acid, and caftaric acid.
Role in Brain Health
Spearmint may support brain health by addressing oxidative stress and supporting a healthy inflammatory response, particularly in the hippocampus, a brain region associated with memory (1, 2). Preliminary research suggests it may help maintain the integrity of the blood-brain barrier and promote healthy neurotransmitter activity, which may contribute to focus and mental clarity (2). Its high rosmarinic acid content is also linked to supporting glial cell health and maintaining a healthy inflammatory response. Supported by 20 peer-reviewed publications, 5 clinical trials, and 3 safety assessments, Neumentix is associated with potential benefits such as enhanced mental focus, memory, and physical performance (1, 3, 4). Its six key mechanisms include addressing oxidative stress, supporting healthy inflammatory responses, promoting neurotrophin and neurotransmitter activity, and encouraging neuronal growth (5).
Axolt Formulation Principles
Our core principle in formulation is to use only the best ingredients. At Axolt, we continuously explore the market to identify top-quality options. How do we define the best? First, we prioritize safety and rely on our rigorous laboratory testing, a standard that not every supplier meets. Second, we ensure the ingredient has proven bioavailability. Lastly, we evaluate the content of the potent substances we seek within the ingredient. For example, with spearmint extract, as with any botanical, polyphenol content can vary greatly depending on the source. Neumentix stands out as a stable, highly versatile ingredient with a proven mix and exceptionally high polyphenol content unmatched by anything else we’ve reviewed.
Core Benefits and Claims
- May help address oxidative stress (4)
- Supports a healthy inflammatory response (5)
- May promote neurotrophin activity (3)
- Contributes to neuronal cell health (1, 2, 3)
- May support neurotransmitter activity (3)
- Encourages healthy neuronal growth (6)
Resources
1. Falcone PH, Tribby AC, Vogel RM, Joy JM, Moon JR, Slayton CA, Henigman MM, Lasrado JA, Lewis BJ, Fonseca BA, Nieman KM, Herrlinger KA. Efficacy of a nootropic spearmint extract on reactive agility: a randomized, double-blind, placebo-controlled, parallel trial. J Int Soc Sports Nutr. 2018 Dec 12;15(1):58. doi: 10.1186/s12970-018-0264-5. PMID: 30541572; PMCID: PMC6291964.
2. Herrlinger KA, Nieman KM, Sanoshy KD, Fonseca BA, Lasrado JA, Schild AL, Maki KC, Wesnes KA, Ceddia MA. Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment. J Altern Complement Med. 2018 Jan;24(1):37-47. doi: 10.1089/acm.2016.0379. Epub 2018 Jan 9. PMID: 29314866; PMCID: PMC5779242.
3. Zhang Y, Jia X, Chen X, Liu Y, Zhao Z, Hao J, Wu R, Feng H, Ren X. L-theanine and Neumentix mixture improves sleep quality and modulates brain neurotransmitter levels in mice. Ann Palliat Med. 2021 Apr;10(4):4572-4581. doi: 10.21037/apm-21-663. PMID: 33966405.
4. Taira Y, Yamashita T, Bian Y, Shang J, Matsumoto N, Sasaki R, Tadokoro K, Nomura E, Tsunoda K, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K. Antioxidative effects of a novel dietary supplement Neumentix in a mouse stroke model. J Stroke Cerebrovasc Dis. 2020 Aug;29(8):104818. doi: 10.1016/j.jstrokecerebrovasdis.2020.104818. Epub 2020 May 19. PMID: 32439352.
5. Bian Y, Yamashita T, Taira Y, Shang J, Tsunoda K, Feng T, Sasaki R, Liu X, Shi X, Tadokoro K, Nomura E, Matsumoto N, Osakada Y, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K. A Polyphenolic Complex Attenuates Inflammatory Response and Blood- Brain Barrier Disruption. Curr Neurovasc Res. 2020;17(3):286-293. doi: 10.2174/1567202617666200517105727. PMID: 32416676.
6. Amato R, Canovai A, Melecchi A, Maci S, Quintela F, Fonseca BA, Cammalleri M, Dal Monte M. Efficacy of a Spearmint (Mentha spicata L.) Extract as Nutritional Support in a Rat Model of Hypertensive Glaucoma. Transl Vis Sci Technol. 2023 Nov 1;12(11):6. doi: 10.1167/tvst.12.11.6. PMID: 37917085; PMCID: PMC10627303.
