Minerals
Magnesium Bisglycinate
Introduction to Magnesium Bisglycinate
Magnesium bisglycinate is a highly bioavailable form of magnesium, an essential mineral involved in over 300 enzymatic reactions within the body (1). By chelating magnesium with glycine, this formulation enhances absorption and reduces gastrointestinal discomfort commonly associated with other forms of magnesium (2, 3). Magnesium bisglycinate is particularly effective in supporting brain function, muscle relaxation, and overall nervous system health (4). Axolt includes this form to optimize magnesium delivery and its cognitive benefits.
Role in Brain Health
Magnesium plays a crucial role in synaptic plasticity, the ability of synapses to strengthen or weaken over time, which is vital for learning and memory (1, 5, 6). Studies have shown that magnesium supplementation may support cognitive function and help regulate mood and occasional stress by regulating neurotransmitter activity (4). The glycine component further contributes to a sense of calm on the brain, making magnesium bisglycinate a dual-action ingredient for mental clarity and emotional balance (5).
Axolt Formulation Principles
Magnesium bisglycinate aligns with Axolt’s commitment to bioavailability and body-native ingredients. The chelation with glycine ensures superior absorption and minimizes side effects, making it an ideal choice for sensitive individuals. Its inclusion in Axolt formulations highlights the brand's focus on synergistic effects, as magnesium bisglycinate complements other nutrients to support overall brain and nervous system health.
Core Benefits and Claims
- Supports synaptic plasticity, which may support learning and memory (6).
- Helps regulate neurotransmitter activity, which may help manage stress and anxiety (4).
- Contributes to relaxation and mental clarity (7).
- May help support sleep quality, which is essential for cognitive health (8).
Resources
- Schwalfenberg GK, Genuis SJ. The Importance of Magnesium in Clinical Healthcare. Scientifica (Cairo). 2017;2017:4179326. Doi: 10.1155/2017/4179326. Epub 2017 Sep 28. PMID: 29093983; PMCID: PMC5637834.
- National Center for Biotechnology Information. PubChem Compound Summary for CID 75487596, Magnesium bisglycinate
- Gröber U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015 Sep 23;7(9):8199-226. Doi: 10.3390/nu7095388. PMID: 26404370; PMCID: PMC4586582.
- Kirkland AE, Sarlo GL, Holton KF. The Role of Magnesium in Neurological Disorders. Nutrients. 2018 Jun 6;10(6):730. Doi: 10.3390/nu10060730. PMID: 29882776; PMCID: PMC6024559.
- Oddoux S, Violette P, Cornet J, Akkoyun-Farinez J, Besnier M, Noël A, Rouillon F. Effect of a Dietary Supplement Combining Bioactive Peptides and Magnesium on Adjustment Disorder with Anxiety: A Clinical Trial in General Practice. Nutrients. 2022 Jun 10;14(12):2425. Doi: 10.3390/nu14122425. PMID: 35745154; PMCID: PMC9228954.
- Huang Y, Huang X, Zhang L, Han F, Pang KL, Li X, Shen JY. Magnesium boosts the memory restorative effect of environmental enrichment in Alzheimer’s disease mice. CNS Neurosci Ther. 2018 Jan;24(1):70-79. Doi: 10.1111/cns.12775. Epub 2017 Nov 10. PMID: 29125684; PMCID: PMC6489792.
- Boyle NB, Billington J, Lawton C, Quadt F, Dye L. A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers. Nutr Neurosci. 2022 Sep;25(9):1845-1859. Doi: 10.1080/1028415X.2021.1909204. Epub 2021 Apr 26. PMID: 33896388.
- Arab A, Rafie N, Amani R, Shirani F. The Role of Magnesium in Sleep Health: a Systematic Review of Available Literature. Biol Trace Elem Res. 2023 Jan;201(1):121-128. Doi: 10.1007/s12011-022-03162-1. Epub 2022 Feb 19. PMID: 35184264.
