Other
adaptogens
L-Theanine
Introduction to L-Theanine
L-Theanine (γ-glutamylethylamide) is an amino acid naturally found in green and black tea (Camellia sinensis) as well as certain types of mushrooms (1). It is associated with promoting relaxation without inducing drowsiness, making it a popular choice for supporting stress resilience and focus (1). Unlike other calming agents, L-Theanine helps provide a sense of ease while maintaining mental alertness, which is why it is often included in supplements aimed at supporting mood and stress management (2, 3).
Role in Brain Health
L-Theanine supports brain health by influencing brain activity due to its ability to cross the blood-brain barrier (BBB). Once in the brain, it plays a key role in modulating key neurotransmitters, including serotonin, dopamine, and GABA, which are associated with normal mood and stress responses (2). By enhancing alpha brain wave activity, L-Theanine is linked to a state of calm focus, characterized by relaxed alertness and supported cognitive function without drowsiness (1). Additionally, L-Theanine supports the integrity of the BBB by contributing to normal oxidative processes and inflammatory responses (4, 5). Research further highlights its role in supporting relaxation and restful sleep, contributing to overall well-being without inducing sedation (1). These properties make L-Theanine a beneficial ingredient in formulations designed to support long-term brain health and mental clarity (1-4).
Axolt Formulation Principles
At Axolt, everything we do is firmly rooted in science. The dosage of each ingredient is carefully selected based on scientific evidence, ensuring that every component is included at levels supported by research. There is always a clear, evidence-backed rationale for the amounts we include—nothing is arbitrary. Unlike many products on the market, we avoid including ingredients simply for marketing purposes. Every ingredient in our formulation is transparently listed, with no hidden proprietary blends. For example, Axolt includes 200 mg of L-Theanine, a dosage supported by research for promoting relaxation and focus (6, 7). This commitment to transparency and evidence-based formulation ensures that Axolt delivers real, measurable benefits to its users.
Core Benefits and Claims
- Resilience: Supports relaxation and focus simultaneously (1, 3).
- Neurochemicals: Plays a role in modulating GABA, dopamine, and serotonin levels (2).
- Healthy Blood-Brain Barrier: Supports oxidative and inflammatory processes (4).
- Neurons: Supports neuronal relaxation and normal excitatory activity (1).
- Glial Cells: Contributes to glial cell function and neuronal health (5).
Resources
1. Li MY, Liu HY, Wu DT, Kenaan A, Geng F, Li HB, Gunaratne A, Li H, Gan RY. L-Theanine: A Unique Functional Amino Acid in Tea (Camellia sinensis L.) With Multiple Health Benefits and Food Applications. Front Nutr. 2022 Apr 4;9:853846. doi: 10.3389/fnut.2022.853846. PMID: 35445053; PMCID: PMC9014247.
2. Liu K, Peng Y, Lin L, Gong Z, Xiao W, Li Y. L-Theanine Regulates the Abundance of Amino Acid Transporters in Mice Duodenum and Jejunum via the mTOR Signaling Pathway. Nutrients. 2022 Dec 28;15(1):142. doi: 10.3390/nu15010142. PMID: 36615799; PMCID: PMC9824403.
3. Baba Y, Inagaki S, Nakagawa S, Kaneko T, Kobayashi M, Takihara T. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study. J Med Food. 2021 Apr;24(4):333-341. doi: 10.1089/jmf.2020.4803. Epub 2021 Mar 22. PMID: 33751906; PMCID: PMC8080935.
4. Kusumoto, K., Habuchi, K., Sakuma, S., & Okuhira, K. (2024). L-Theanine protects against methylglyoxal-induced oxidative stress and tight junction disruption in human cerebral microvascular endothelial cells. Food and Nutrition Sciences, 15(12), 1137-1149. https://doi.org/10.4236/fns.2024.1512077
5. Takeshima M, Miyazaki I, Murakami S, Kita T, Asanuma M. l-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes. J Clin Biochem Nutr. 2016 Sep;59(2):93-99. doi: 10.3164/jcbn.16-15. Epub 2016 Jul 16. PMID: 27698535; PMCID: PMC5018574.
6. Williams, J., Kellett, J., Roach, P. D., McKune, A., Mellor, D., Thomas, J., & Naumovski, N. (2016). l-Theanine as a Functional Food Additive: Its Role in Disease Prevention and Health Promotion. Beverages, 2(2), 13. https://doi.org/10.3390/beverages2020013
7. Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39-45. doi: 10.1016/j.biopsycho.2006.06.006. Epub 2006 Aug 22. PMID: 16930802.
