Botanicals & Natural substances
Rutin
Introduction to Rutin
Rutin is a natural flavonoid glycoside commonly found in buckwheat, citrus fruits, apples, and tea. It has strong antioxidant properties and is known for supporting vascular health. Rutin helps maintain blood vessel integrity and supports overall circulatory function. When combined with vitamin C, its effects are further enhanced due to their synergistic interaction.
Role in Brain Health
Rutin helps maintain blood-brain barrier (BBB) integrity by supporting endothelial cell function (2). . It enhances brain blood flow, ensuring neurons and other cells receive adequate oxygen and nutrients (4). Rutin is also being studied for its potential role in supporting brain health as the body ages (5).
Axolt Formulation Principles
Axolt's approach to long-term brain health is systemic. First and foremost, we recognize the importance of supporting and strengthening the body’s and brain's natural systems to ensure they function optimally. Only then can we effectively provide the building blocks, such as vitamins, minerals, and other beneficial substances, to support cognitive function and overall well-being.
Blood flow and the blood-brain barrier—in other words, **the brain’s natural delivery and protection systems—**are the foundation of Axolt's Brain Health Pyramid. Rutin, in combination with Vitamin C, supports both systems directly (6).
Blood flow and the blood-brain barrier—in other words, **the brain’s natural delivery and protection systems—**are the foundation of Axolt's Brain Health Pyramid. Rutin, in combination with Vitamin C, supports both systems directly (6).
Core Benefits and Claims
- Supports endothelial cell function, which plays a role in vascular health (2).
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Supports blood flow and thus oxygen and nutrient delivery to the brain (4).
Resources
1. Calabrese EJ, Pressman P, Hayes AW, Dhawan G, Kapoor R, Agathokleous E, Calabrese V. RUTIN, a widely consumed flavonoid, that commonly induces hormetic effects. Food Chem Toxicol. 2024 May;187:114626. doi: 10.1016/j.fct.2024.114626. Epub 2024 Mar 29. PMID: 38556157.
2. Li Y, Qin R, Yan H, Wang F, Huang S, Zhang Y, Zhong M, Zhang W, Wang Z. Inhibition of vascular smooth muscle cells premature senescence with rutin attenuates and stabilizes diabetic atherosclerosis. J Nutr Biochem. 2018 Jan;51:91-98. doi: 10.1016/j.jnutbio.2017.09.012. Epub 2017 Sep 28. PMID: 29107826.
3. An R, Shi C, Tang Y, Cui Z, Li Y, Chen Z, Xiao M, Xu L. Chitosan/rutin multifunctional hydrogel with tunable adhesion, anti-inflammatory and antibacterial properties for skin wound healing. Carbohydr Polym. 2024 Nov 1;343:122492. doi: 10.1016/j.carbpol.2024.122492. Epub 2024 Jul 16. Erratum in: Carbohydr Polym. 2025 Jan 1;347:122844. doi: 10.1016/j.carbpol.2024.122844. PMID: 39174142.
4. Bazyar H, Zare Javid A, Ahangarpour A, Zaman F, Hosseini SA, Zohoori V, Aghamohammadi V, Yazdanfar S, Ghasemi Deh Cheshmeh M. The effects of rutin supplement on blood pressure markers, some serum antioxidant enzymes, and quality of life in patients with type 2 diabetes mellitus compared with placebo. Front Nutr. 2023 Aug 3;10:1214420. doi: 10.3389/fnut.2023.1214420. PMID: 37599700; PMCID: PMC10435270.
5. Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, Hou SJ, Yu XL, Liu RT. Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease. J Neuroinflammation. 2021 Jun 11;18(1):131. doi: 10.1186/s12974-021-02182-3. PMID: 34116706; PMCID: PMC8196535.
6. Ragheb SR, El Wakeel LM, Nasr MS, Sabri NA. Impact of Rutin and Vitamin C combination on oxidative stress and glycemic control in patients with type 2 diabetes. Clin Nutr ESPEN. 2020 Feb;35:128-135. doi: 10.1016/j.clnesp.2019.10.015. Epub 2019 Nov 14. PMID: 31987106.
