Minerals

Potassium Citrate

Potassium Citrate supports:

Boosts neural conductivity
Supports electrolyte balance
Promotes neuroprotection

Potassium Citrate on Axolt’s brain health pyramid

Healthy Inflammatory Response
Balanced Neurochemicals & Synapses

Introduction to Potassium Citrate

Potassium citrate is a bioavailable form of potassium, an essential mineral and electrolyte necessary for maintaining proper cellular functions, including fluid balance, muscle contractions, and nerve signaling (1, 2, 3). Its citrate component adds alkalizing properties, which can help reduce acidity in the body and support metabolic balance (1, 2, 4). Axolt incorporates potassium citrate into its formulations to support overall cellular health and brain function.

Role in Brain Health

Research has shown that adequate potassium levels are crucial for maintaining healthy neuron activity and may play a role in reducing the risk of cognitive decline (5). Potassium citrate supports the brain by optimizing electrical signaling between neurons, ensuring efficient communication throughout the nervous system. Furthermore, its alkalizing properties can reduce oxidative stress and inflammation, supporting an environment conducive to brain health and neuroprotection (6).

Axolt Formulation Principles

Incorporating potassium citrate aligns with Axolt’s principles of using body-native and bioavailable ingredients. The choice of potassium citrate ensures high absorption rates, making the mineral readily accessible to the body for immediate use. Additionally, its dual role as an electrolyte and alkalizing agent complements other Axolt ingredients, further supporting overall brain and cellular health in synergistic formulations.

Core Benefits and Claims

Supports neural conductivity and efficient brain signaling (1-3, 8).
Helps maintain electrolyte balance, critical for cognitive function and focus (7).
May help reduce oxidative stress and support neuroprotection through alkalizing effects (6).
Supports cognitive health by promoting cellular and metabolic health (5).

Resources

Wouda RD, Gritter M, Karsten M, Michels EHA, Nieuweboer TM, Danser AHJ, de Borst MH, Hoorn EJ, Rotmans JI, Vogt L. Kaliuresis and Intracellular Uptake of Potassium with Potassium Citrate and Potassium Chloride Supplements: A Randomized Controlled Trial. Clin J Am Soc Nephrol. 2023 Oct 1;18(10):1260-1271. doi: 10.2215/CJN.0000000000000228. Epub 2023 Jun 29. PMID: 37382933; PMCID: PMC10578626.
Wong DG, Elson L, Nottingham CU, Desai AC. Pharmaceutical versus Over-the-Counter Potassium Citrate: A Benchtop Comparison. Urol Pract. 2022 May;9(3):205-211. doi: 10.1097/UPJ.0000000000000300. Epub 2022 Feb 9. PMID: 37145541.
Uçar M, Akkoc A, Topcuoglu M, Ozturk SA, Demir M. The Effect of Potassium Citrate on Overactive Bladder Disease: A Cross-sectional Study. J Coll Physicians Surg Pak. 2020 Dec;30(12):1301-1305. doi: 10.29271/jcpsp.2020.12.1301. PMID: 33397057.
Bjurulf B, Magnus P, Hallböök T, Strømme P. Potassium citrate and metabolic acidosis in children with epilepsy on the ketogenic diet: a prospective controlled study. Dev Med Child Neurol. 2020 Jan;62(1):57-61. doi: 10.1111/dmcn.14393. Epub 2019 Nov 19. PMID: 31745987.
Vintimilla RM, Large SE, Gamboa A, Rohlfing GD, O'Jile JR, Hall JR, O'Bryant SE, Johnson LA. The Link between Potassium and Mild Cognitive Impairment in Mexican-Americans. Dement Geriatr Cogn Dis Extra. 2018 Apr 24;8(1):151-157. doi: 10.1159/000488483. PMID: 29805381; PMCID: PMC5968281.
Vongpatanasin W, Peri-Okonny P, Velasco A, Arbique D, Wang Z, Ravikumar P, Adams-Huet B, Moe OW, Pak CYC. Effects of Potassium Magnesium Citrate Supplementation on 24-Hour Ambulatory Blood Pressure and Oxidative Stress Marker in Prehypertensive and Hypertensive Subjects. Am J Cardiol. 2016 Sep 15;118(6):849-853. doi: 10.1016/j.amjcard.2016.06.041. Epub 2016 Jun 28. PMID: 27448942; PMCID: PMC5021576.
Terker AS, Zhang C, McCormick JA, Lazelle RA, Zhang C, Meermeier NP, Siler DA, Park HJ, Fu Y, Cohen DM, Weinstein AM, Wang WH, Yang CL, Ellison DH. Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride. Cell Metab. 2015 Jan 6;21(1):39-50. doi: 10.1016/j.cmet.2014.12.006. PMID: 25565204; PMCID: PMC4332769.
Peacock JM, Orchardson R. Effects of potassium ions on action potential conduction in A- and C-fibers of rat spinal nerves. J Dent Res. 1995 Feb;74(2):634-41. doi: 10.1177/00220345950740020301. PMID: 7722060.