Essential brain nutrients

L-Tyrosine

L-Tyrosine supports:

Supports resilience & mental clarity
Helps maintain focus during demanding situations
Contributes to a positive mental outlook

L-Tyrosine on Axolt’s brain health pyramid

Efficient Neurons
Plentiful and Functioning Mitochondria
Balanced Neurochemicals & Synapses

Introduction to L-Tyrosine

L-Tyrosine is an amino acid naturally present in protein-rich foods such as fish, eggs, nuts, seeds, and legumes. It plays a role in the body’s natural production of neurotransmitters, including dopamine, norepinephrine, and epinephrine (also called as noradrenaline, adrenaline), which are involved in maintaining cognitive function and stress management (1).During periods of stress or fatigue, the body’s ability to produce these neurotransmitters may be challenged, and L-Tyrosine supplementation can support the body’s natural response (2).

Axolt’s formula emphasizes long-term brain health, but some ingredients act almost immediately, L-Tyrosine is one of them.

Role in Brain Health

In times of high mental or physical demand, such as during intensive exercise or workloads, the body’s need for neurotransmitter production increases.Supplementing with L-Tyrosine can support the body’s natural ability to maintain focus and cognitive performance under these conditions (3).Additionally, L-Tyrosine contributes to the natural interaction between neurotransmitters and overall neural health, helping sustain cognitive function during stressful periods (5, 6).

Axolt Formulation Principles

Long-term brain health and enhanced cognitive capacity is one of the principles followed by Axolt’s scientific team. L-Tyrosine with L-Citruline are exceptions that act right away without long-term side effects, unlike stimulants. (7)

L-Tyrosine, in particular, helps the body maintain focus and mental clarity during moments of increased stress (8).

Core Benefits and Claims

Supports neurotransmitter production: L-Tyrosine contributes to the body’s natural synthesis of dopamine and norepinephrine (8).
Helps maintain focus under stress: Supplementing with L-Tyrosine supports cognitive performance during demanding situations (2, 5).
Encourages neuronal resilience: L-Tyrosine aids in sustaining healthy neural function during periods of stress (9).

Resources

Jongkees BJ. Baseline-dependent effect of dopamine's precursor L-tyrosine on working memory gating but not updating. Cogn Affect Behav Neurosci. 2020 Jun;20(3):521-535. doi: 10.3758/s13415-020-00783-8. PMID: 32133585; PMCID: PMC7266860.
Jongkees BJ, Hommel B, Kühn S, Colzato LS. Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A review. J Psychiatr Res. 2015 Nov;70:50-7. doi: 10.1016/j.jpsychires.2015.08.014. Epub 2015 Aug 25. PMID: 26424423.
Gonzalez AM, Trexler ET. Effects of Citrulline Supplementation on Exercise Performance in Humans: A Review of the Current Literature. J Strength Cond Res. 2020 May;34(5):1480-1495. doi: 10.1519/JSC.0000000000003426. PMID: 31977835.
Bloemendaal M, Froböse MI, Wegman J, Zandbelt BB, van de Rest O, Cools R, Aarts E. Neuro-Cognitive Effects of Acute Tyrosine Administration on Reactive and Proactive Response Inhibition in Healthy Older Adults. eNeuro. 2018 Apr 30;5(2):ENEURO.0035-17.2018. doi: 10.1523/ENEURO.0035-17.2018. PMID: 30094335; PMCID: PMC6084775.
Hase A, Jung SE, aan het Rot M. Behavioral and cognitive effects of tyrosine intake in healthy human adults. Pharmacol Biochem Behav. 2015 Jun;133:1-6. doi: 10.1016/j.pbb.2015.03.008. Epub 2015 Mar 20. PMID: 25797188.
Gaskill PJ, Khoshbouei H. Dopamine and norepinephrine are embracing their immune side and so should we. Curr Opin Neurobiol. 2022 Dec;77:102626. doi: 10.1016/j.conb.2022.102626. Epub 2022 Sep 1. PMID: 36058009; PMCID: PMC10481402.
Glaeser BS, Melamed E, Growdon JH, Wurtman RJ. Elevation of plasma tyrosine after a single oral dose of L-tyrosine. Life Sci. 1979 Jul 16;25(3):265-71. doi: 10.1016/0024-3205(79)90294-7. PMID: 481129.
Fernstrom JD, Fernstrom MH. Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. J Nutr. 2007 Jun;137(6 Suppl 1):1539S-1547S; discussion 1548S. doi: 10.1093/jn/137.6.1539S. PMID: 17513421.
Institute of Medicine (US) Committee on Military Nutrition Research; Marriott BM, editor. Food Components to Enhance Performance: An Evaluation of Potential Performance-Enhancing Food Components for Operational Rations. Washington (DC): National Academies Press (US); 1994. 15, Tyrosine and Stress: Human and Animal Studies. Available from: https://www.ncbi.nlm.nih.gov/books/NBK209061/