Other
adaptogens
Gotu Kola
Introduction to Gotu-Kola
Gotu Kola (Centella asiatica) is a key ingredient in Axolt’s formulations, selected for its long history of use in traditional Ayurvedic and Chinese practices. It plays a role in brain health by supporting neuronal function and contributing to brain-derived neurotrophic factor (BDNF) levels. Rich in polyphenols, Gotu Kola also provides antioxidant support, helping to neutralize free radicals and support overall brain function. By including Gotu Kola, Axolt enhances polyphenol diversity in its formulations for a well-rounded botanical blend.
Role in Brain Health
Gotu Kola supports brain health by supporting neuronal growth and synaptic activity, which are essential for memory and learning (3). Its antioxidant and supports the body's natural defenses against oxidative stress (2, 4).
Additionally, Gotu Kola is associated with supporting healthy circulation, which helps transport oxygen and nutrients to brain cells (6).
Additionally, Gotu Kola is associated with supporting healthy circulation, which helps transport oxygen and nutrients to brain cells (6).
Axolt Formulation Principles
At Axolt, our main goal is to promote long-term brain health, and Gotu Kola aligns with this mission. While Gotu Kola offers immediate effects, such as reducing inflammation, its most valuable benefit lies in its potential to support brain function over time through brain-derived neurotrophic factor (BDNF) (3). By supporting the brain’s ability to maintain function, Gotu Kola becomes an excellent ingredient for long-term cognitive health, aligning with Axolt’s commitment to lasting brain wellness.
Core Benefits and Claims
- Supports neuronal function and synaptic activity. Supports synaptic plasticity, memory and learning (1, 5).
- Provides antioxidant support for overall brain health. (2, 4).
- Supports cerebral circulation, which plays a role in nutrient and oxygen delivery to the brain, indirectly supporting mental clarity (6).
-
Supports long-term brain resilience through neurogenesis (1, 3).
Resources
1. Chandrika UG, Prasad Kumarab PA. Gotu Kola (Centella asiatica): Nutritional Properties and Plausible Health Benefits. Adv Food Nutr Res. 2015;76:125-57. doi: 10.1016/bs.afnr.2015.08.001. Epub 2015 Oct 1. PMID: 26602573.
2. Sbrini G, Brivio P, Fumagalli M, Giavarini F, Caruso D, Racagni G, Dell'Agli M, Sangiovanni E, Calabrese F. Centella asiatica L. Phytosome Improves Cognitive Performance by Promoting Bdnf Expression in Rat Prefrontal Cortex. Nutrients. 2020 Jan 29;12(2):355. doi: 10.3390/nu12020355. PMID: 32013132; PMCID: PMC7071263.
3. Sari DCR, Arfian N, Tranggono U, Setyaningsih WAW, Romi MM, Emoto N. Centella asiatica (Gotu kola) ethanol extract up-regulates hippocampal brain-derived neurotrophic factor (BDNF), tyrosine kinase B (TrkB) and extracellular signal-regulated protein kinase 1/2 (ERK1/2) signaling in chronic electrical stress model in rats. Iran J Basic Med Sci. 2019 Oct;22(10):1218-1224. doi: 10.22038/ijbms.2019.29012.7002. PMID: 31998466; PMCID: PMC6885393.
4. Ariani A, Khotimah H, Sulistyarini A, Daniaridevi AS. Centella asiatica extract ameliorates deoxygenation-induced neurological dysfunction in zebrafish larvae. Open Vet J. 2024 May;14(5):1154-1160. doi: 10.5455/OVJ.2024.v14.i5.9. Epub 2024 May 31. PMID: 38938421; PMCID: PMC11199753.
5. Pairojana T, Phasuk S, Tantisira MH, Liang KC, Roytrakul S, Pakaprot N, Chompoopong S, Nudmamud-Thanoi S, Ming Y, Liu IY. Standardized Extract of Centella asiatica Prevents Fear Memory Deficit in 3xTg-AD Mice. Am J Chin Med. 2023;51(2):329-353. doi: 10.1142/S0192415X23500179. Epub 2023 Jan 25. PMID: 36695831.
6. Rosyidi RM, Rusidi HA, Januarman J, Priyanto B, Wardhana DPW, Rozikin R, Wahyudi W, Baskoro W. Centella asiatica effect on traumatic brain injury: A systematic review. Surg Neurol Int. 2024 Jul 19;15:248. doi: 10.25259/SNI_176_2024. PMID: 39108365; PMCID: PMC11301788.
7. Lee J, Seroogy KB, Mattson MP. Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice. J Neurochem. 2002 Feb;80(3):539-47. doi: 10.1046/j.0022-3042.2001.00747.x. PMID: 11905999.
