Botanicals & Natural substances
Fisetin
Introduction to Fisetin
Fisetin is a naturally occurring flavonoid found in strawberries, apples, onions, and other fruits and vegetables. It has strong antioxidant and anti-inflammatory properties and is being explored for its role in brain health. Research suggests that Fisetin may help maintain cellular function by supporting the body's natural ability to manage aging or "senescent" cells. These are older, non-functioning cells that accumulate over time and may contribute to inflammation. By assisting in the body's natural cell-clearing processes, Fisetin supports overall cellular health and longevity.
Role in Brain Health
Fisetin supports brain health by reducing oxidative stress and inflammation in the brain. Fisetin is being studied for its potential to support the body's natural ability to manage aging or senescent cells. It supports the brain’s natural processes involved in waste clearance (glymphatic) (3, 5). Additionally, Fisetin is associated with supporting neuroplasticity and brain cell function.
Axolt Formulation Principles
Axolt is dedicated to supporting long-term brain health. Our mission is to provide everything your brain needs to perform at its peak today, without relying on stimulants or certain nootropics that may harm future cognitive capacity, while preserving its functionality for years to come. We also focus on helping those already experiencing signs of cognitive decline. One key factor in this decline is the presence of "zombie cells," or senescent cells. These damaged cells typically get cleared by the brain, but as this process weakens with age, the cells linger and cause trouble. They behave like zombies, spreading damage and creating more dysfunctional cells. Fisetin, a natural compound, helps the brain clear these harmful cells and is being explored for its role in supporting the body's natural cell maintenance processes (3, 7).
Core Benefits and Claims
- Supports the brain’s natural waste clearance processes (3).
- Helps maintain neuronal health and supports brain cell function (1).
- Supports the integrity of the blood-brain barrier (8).
- Supports brain-derived neurotrophic factor (BDNF) levels, which play a role in brain health.
Resources
1. Pal HC, Pearlman RL, Afaq F. Fisetin and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016;928:213-244. doi: 10.1007/978-3-319-41334-1_10. PMID: 27671819.
2. Tang X, Deng P, Jiang Y, Zhang L, He Y, Yang H. An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways. Biomedicines. 2023 Oct 24;11(11):2878. doi: 10.3390/biomedicines11112878. PMID: 38001882; PMCID: PMC10669030.
3. Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29. PMID: 30279143; PMCID: PMC6197652.
4. McHugh D, Gil J. Senescence and aging: Causes, consequences, and therapeutic avenues. J Cell Biol. 2018 Jan 2;217(1):65-77. doi: 10.1083/jcb.201708092. Epub 2017 Nov 7. PMID: 29114066; PMCID: PMC5748990.
5. Ahmad A, Ali T, Park HY, Badshah H, Rehman SU, Kim MO. Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice. Mol Neurobiol. 2017 Apr;54(3):2269-2285. doi: 10.1007/s12035-016-9795-4. Epub 2016 Mar 5. PMID: 26944285.
6. ordaro M, D'Amico R, Fusco R, Peritore AF, Genovese T, Interdonato L, Franco G, Arangia A, Gugliandolo E, Crupi R, Siracusa R, Di Paola R, Cuzzocrea S, Impellizzeri D. Discovering the Effects of Fisetin on NF-κB/NLRP-3/NRF-2 Molecular Pathways in a Mouse Model of Vascular Dementia Induced by Repeated Bilateral Carotid Occlusion. Biomedicines. 2022 Jun 19;10(6):1448. doi: 10.3390/biomedicines10061448. PMID: 35740470; PMCID: PMC9221103.
7. Mahoney SA, Venkatasubramanian R, Darrah MA, Ludwig KR, VanDongen NS, Greenberg NT, Longtine AG, Hutton DA, Brunt VE, Campisi J, Melov S, Seals DR, Rossman MJ, Clayton ZS. Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence. Aging Cell. 2024 Mar;23(3):e14060. doi: 10.1111/acel.14060. Epub 2023 Dec 7. PMID: 38062873; PMCID: PMC10928570.
8. Mehra S, Ahsan AU, Sharma M, Budhwar M, Chopra M. Gestational Fisetin Exerts Neuroprotection by Regulating Mitochondria-Directed Canonical Wnt Signaling, BBB Integrity, and Apoptosis in Prenatal VPA-Induced Rodent Model of Autism. Mol Neurobiol. 2024 Jul;61(7):4001-4020. doi: 10.1007/s12035-023-03826-6. Epub 2023 Dec 4. PMID: 38048031.
