The Gut-Brain Axis: Your Inner Superhighway to Mental Wellness
Your gut and brain are in constant communication and the quality of that conversation affects everything from your mood to your mental clarity. This powerful connection is called the gut-brain axis, and it's one of the most exciting frontiers in health science today.
In this article, you'll learn how your gut influences your brain, why nurturing this connection matters, and what practical steps you can take to feel better, think clearer, and thrive.
What is the Gut-Brain Axis?
The gut-brain axis is the communication network linking your digestive system to your central nervous system (1). This isn’t just metaphorical. Your gut contains over 100 million neurons and produces many of the same neurotransmitters as your brain (2). Scientists now call it the "second brain."
When this network is balanced, you experience benefits like improved mood, sharper thinking, better sleep, and reduced stress (3). But when it’s out of balance, symptoms like brain fog, mood swings, and chronic inflammation can emerge (4, 5).
How Your Gut Talks to Your Brain
There are three key ways your gut and brain stay in touch:
- Enteric Nervous System (ENS): This "second brain" independently regulates digestion and sends mood-influencing signals to the brain (6).
- Vagus Nerve: A two-way information superhighway managing mood, inflammation, and stress response (7).
- Gut Microbiome: Trillions of microbes that produce neurotransmitters like serotonin, dopamine, and GABA, as well as short-chain fatty acids (SCFAs) that support mental health (8).
Together, these systems ensure continuous feedback between your gut and your brain.
Gut Health and Mental Wellbeing
When the microbiome becomes imbalanced, a condition known as dysbiosis, you may experience increased inflammation, reduced serotonin production, and a heightened risk for anxiety and depression (9, 10). Brain fog and fatigue often follow, making it harder to concentrate or feel emotionally balanced (11).
Since about 90% of serotonin is made in the gut, your microbiome plays a central role in emotional regulation and cognitive clarity (12).
Foods and Habits to Improve the Gut-Brain Axis
Your daily food choices are a powerful tool for influencing your gut-brain axis. A gut-friendly diet doesn’t just support digestion—it actively regulates mood, energy, focus, and long-term cognitive resilience (13).
Foods That Feed the Good Bacteria
To support beneficial gut bacteria, prioritize best foods for gut-brain axis that are rich in soluble fiber like lentils, leafy greens, and raspberries. These fibers help stabilize blood sugar and lower inflammation (14). Polyphenol-rich foods such as blueberries, olive oil, green tea, and dark chocolate act as antioxidants and nourish your microbiome (15). Fermented foods like yogurt, kefir, and kimchi introduce additional beneficial bacteria directly into your digestive system (16).
Probiotics vs. Prebiotics: What’s the Difference?
Probiotics are live, beneficial bacteria typically consumed through fermented foods or supplements (17). Prebiotics are the fibers that feed those bacteria—think oats, bananas, and onions (18). The combination of both helps your gut ecosystem flourish. Think of probiotics as the seeds and prebiotics as the fertilizer.
How Sugar and Processed Foods Disrupt the Gut Brain Axis
Refined sugars and ultra-processed foods feed harmful microbes and disrupt microbial balance. This contributes to systemic inflammation, impaired neurotransmitter function, and even cognitive decline (19).
Lifestyle Tips to Naturally Boost Gut-Brain Health
Daily habits go hand-in-hand with diet when it comes to nurturing your gut-brain axis. Simple, consistent practices can have a powerful impact on mental clarity and mood stability.
1. Eat a variety of high-fiber, whole foods — These help boost BDNF (brain-derived neurotrophic factor), a protein essential for learning and memory. Including colorful, polyphenol-rich plants, like berries, mint, onions, and green tea - adds further support for your brain and microbiome (20).
2. Exercise regularly — Physical activity stimulates vagus nerve activity and enhances microbial diversity (21).
3. Prioritize quality sleep — Following consistent sleep routines helps maintain gut integrity and stabilizes your circadian rhythm (22).
4. Maintain strong social connections — Positive relationships reinforce emotional well-being and cognitive resilience (23).
5. Minimize processed foods and added sugars — Reducing these can lower inflammation and support neurotransmitter balance (24).
How Axolt Supports the Gut-Brain Axis
Axolt is thoughtfully crafted to nourish both your gut and brain using two natural, research-backed powerhouses: soluble fiber and polyphenols.
- Soluble fiber in Axolt acts as a prebiotic, feeding beneficial gut bacteria and regulating blood sugar. This helps prevent energy crashes, enhances focus, and supports the production of BDNF—a key protein for neuroplasticity and memory.
- Polyphenols, sourced from real fruits and vegetables, reduce inflammation and support neurotransmitter balance. These colorful compounds modulate immune and metabolic pathways that influence brain health and resilience.
In simple terms, Axolt brings together nature’s most powerful brain-supportive ingredients into one convenient daily drink. It’s designed to help you think clearer, feel calmer, and function at your best—starting with your gut.
Frequently Asked Questions
Q: How do I know if my gut-brain axis is out of balance?
A: Common signs include brain fog, mood swings, poor digestion, fatigue, and trouble sleeping.
A: Common signs include brain fog, mood swings, poor digestion, fatigue, and trouble sleeping.
Q: Can changing my diet really improve my mental health?
A: Yes. A diet rich in fiber, polyphenols, and fermented foods has been shown to improve mood, reduce anxiety, and support cognitive function.
A: Yes. A diet rich in fiber, polyphenols, and fermented foods has been shown to improve mood, reduce anxiety, and support cognitive function.
Q: What makes Axolt different from other supplements?
A: Axolt combines targeted gut-supportive nutrients with brain-enhancing compounds, making it one of the few supplements designed to nourish both ends of the gut-brain axis.
A: Axolt combines targeted gut-supportive nutrients with brain-enhancing compounds, making it one of the few supplements designed to nourish both ends of the gut-brain axis.
Q: Is Axolt safe to use daily?
A: Absolutely. Axolt is formulated for daily use, but as with any supplement, consult your healthcare provider if you have specific medical conditions.
A: Absolutely. Axolt is formulated for daily use, but as with any supplement, consult your healthcare provider if you have specific medical conditions.
Ready to support your gut and brain in one daily habit?
Discover how Axolt can help you feel your best →
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References
1. Schneider E, O'Riordan KJ, Clarke G, Cryan JF. Feeding gut microbes to nourish the brain: unravelling the diet-microbiota-gut-brain axis. Nat Metab. 2024 Aug;6(8):1454-1478. doi: 10.1038/s42255-024-01108-6. Epub 2024 Aug 22. PMID: 39174768.
2. Michel K, Kuch B, Dengler S, Demir IE, Zeller F, Schemann M. How big is the little brain in the gut? Neuronal numbers in the enteric nervous system of mice, Guinea pig, and human. Neurogastroenterol Motil. 2022 Dec;34(12):e14440. doi: 10.1111/nmo.14440. Epub 2022 Aug 5. PMID: 35929768.
3. Tingö L, Bergh C, Rode J, Rubio MFR, Persson J, Johnson LB, Smit LH, Hutchinson AN. The Effect of Whole-Diet Interventions on Memory and Cognitive Function in Healthy Older Adults - A Systematic Review. Adv Nutr. 2024 Sep;15(9):100291. doi: 10.1016/j.advnut.2024.100291. Epub 2024 Aug 19. PMID: 39154864; PMCID: PMC11405642.
4. Lutz M, Arancibia M, Moran-Kneer J, Manterola M. Ultraprocessed Foods and Neuropsychiatric Outcomes: Putative Mechanisms. Nutrients. 2025 Mar 30;17(7):1215. doi: 10.3390/nu17071215. PMID: 40218973; PMCID: PMC11990412.
5. Altinsoy C, Dikmen D. How Are Brain Fog Symptoms Related to Diet, Sleep, Mood and Gastrointestinal Health? A Cross-Sectional Study. Medicina (Kaunas). 2025 Feb 15;61(2):344. doi: 10.3390/medicina61020344. PMID: 40005460; PMCID: PMC11857395.
6. Kammar, M.R. et al. (2024) ‘Gut feelings: How microbes influence neurological disorders’, Biochemical and Cellular Archives, 24(1). doi:10.51470/bca.2024.24.1-s.3217.
7. Wang Y, Duan C, Du X, Zhu Y, Wang L, Hu J, Sun Y. Vagus Nerve and Gut-Brain Communication. Neuroscientist. 2024 Jul 23:10738584241259702. doi: 10.1177/10738584241259702. Epub ahead of print. PMID: 39041416.
8. Appleton J. The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health. Integr Med (Encinitas). 2018 Aug;17(4):28-32. PMID: 31043907; PMCID: PMC6469458.
9. Margolis KG, Cryan JF, Mayer EA. The Microbiota-Gut-Brain Axis: From Motility to Mood. Gastroenterology. 2021 Apr;160(5):1486-1501. doi: 10.1053/j.gastro.2020.10.066. Epub 2021 Jan 22. PMID: 33493503; PMCID: PMC8634751.
10. Bremner JD, Moazzami K, Wittbrodt MT, Nye JA, Lima BB, Gillespie CF, Rapaport MH, Pearce BD, Shah AJ, Vaccarino V. Diet, Stress and Mental Health. Nutrients. 2020 Aug 13;12(8):2428. doi: 10.3390/nu12082428. PMID: 32823562; PMCID: PMC7468813.
11. Mitchell J, Kim SJ, Howe C, Lee S, Her JY, Patel M, Kim G, Lee J, Im E, Rhee SH. Chronic Intestinal Inflammation Suppresses Brain Activity by Inducing Neuroinflammation in Mice. Am J Pathol. 2022 Jan;192(1):72-86. doi: 10.1016/j.ajpath.2021.09.006. Epub 2021 Oct 5. PMID: 34619134; PMCID: PMC8759038.
12. Hwang YK, Oh JS. Interaction of the Vagus Nerve and Serotonin in the Gut-Brain Axis. Int J Mol Sci. 2025 Jan 29;26(3):1160. doi: 10.3390/ijms26031160. PMID: 39940928; PMCID: PMC11818468.
13. Tooley KL. Effects of the Human Gut Microbiota on Cognitive Performance, Brain Structure and Function: A Narrative Review. Nutrients. 2020 Sep 30;12(10):3009. doi: 10.3390/nu12103009. PMID: 33007941; PMCID: PMC7601389.
14. Kumar S, Mukherjee R, Gaur P, Leal É, Lyu X, Ahmad S, Puri P, Chang CM, Raj VS, Pandey RP. Unveiling roles of beneficial gut bacteria and optimal diets for health. Front Microbiol. 2025 Feb 18;16:1527755. doi: 10.3389/fmicb.2025.1527755. PMID: 40041870; PMCID: PMC11877911.
15. Wang X, Qi Y, Zheng H. Dietary Polyphenol, Gut Microbiota, and Health Benefits. Antioxidants (Basel). 2022 Jun 20;11(6):1212. doi: 10.3390/antiox11061212. PMID: 35740109; PMCID: PMC9220293.
16. Leeuwendaal NK, Stanton C, O'Toole PW, Beresford TP. Fermented Foods, Health and the Gut Microbiome. Nutrients. 2022 Apr 6;14(7):1527. doi: 10.3390/nu14071527. PMID: 35406140; PMCID: PMC9003261.
17. Fehily SR, Basnayake C, Wright EK, Yao CK, Godsell J, Gibson PR, Kamm MA. Probiotics: are they beneficial? Intern Med J. 2024 Jun;54(6):861-870. doi: 10.1111/imj.16388. Epub 2024 May 8. PMID: 38717051.
18. Luzzi A, Briata IM, Di Napoli I, Giugliano S, Di Sabatino A, Rescigno M, Cena H. Prebiotics, probiotics, synbiotics and postbiotics to adolescents in metabolic syndrome. Clin Nutr. 2024 Jun;43(6):1433-1446. doi: 10.1016/j.clnu.2024.04.032. Epub 2024 Apr 22. PMID: 38704983.
19. Rondinella D, Raoul PC, Valeriani E, Venturini I, Cintoni M, Severino A, Galli FS, Mora V, Mele MC, Cammarota G, Gasbarrini A, Rinninella E, Ianiro G. The Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier. Nutrients. 2025 Feb 28;17(5):859. doi: 10.3390/nu17050859. PMID: 40077728; PMCID: PMC11901572.
20. Gravesteijn E, Mensink RP, Plat J. Effects of nutritional interventions on BDNF concentrations in humans: a systematic review. Nutr Neurosci. 2022 Jul;25(7):1425-1436. doi: 10.1080/1028415X.2020.1865758. Epub 2021 Jan 10. PMID: 33427118.
21. Monda V, Villano I, Messina A, Valenzano A, Esposito T, Moscatelli F, Viggiano A, Cibelli G, Chieffi S, Monda M, Messina G. Exercise Modifies the Gut Microbiota with Positive Health Effects. Oxid Med Cell Longev. 2017;2017:3831972. doi: 10.1155/2017/3831972. Epub 2017 Mar 5. PMID: 28357027; PMCID: PMC5357536.
22. Palve S, Singh S, Palve S, Lanka K. Balancing your mind and gut: Exploring the influence of sleep and gut health on emotional well-being. J Educ Health Promot. 2024 Oct 28;13:390. doi: 10.4103/jehp.jehp_1157_23. PMID: 39703630; PMCID: PMC11657905.
23. Gloria CT, Steinhardt MA. Relationships Among Positive Emotions, Coping, Resilience and Mental Health. Stress Health. 2016 Apr;32(2):145-56. doi: 10.1002/smi.2589. Epub 2014 Jun 24. PMID: 24962138.
24. Kurowska A, Ziemichód W, Herbet M, Piątkowska-Chmiel I. The Role of Diet as a Modulator of the Inflammatory Process in the Neurological Diseases. Nutrients. 2023 Mar 16;15(6):1436. doi: 10.3390/nu15061436. PMID: 36986165; PMCID: PMC10057655.