Axolt’s Brain Health Pyramid: How We Crafted Our Science-Based Formula

Discussions about brain health often focus on neurons and neurotransmitters,  emphasizing processes like neurogenesis and synaptogenesis as key drivers of cognitive function. However, these processes represent only the surface of the brain’s incredibly complex biological system. For this system to function at its best, it needs a solid foundation. At the base of this foundation lies the gut-brain axis, often overlooked but essential to overall brain health.

A healthy gut contributes to maintaining overall cognitive wellness (1), but it doesn't work alone. Equally important are supporting a healthy inflammatory response*, maintaining the integrity of the blood-brain barrier*, and promoting the brain’s natural detox system* (2, 3). The brain’s vascular system also plays a key role in delivering nutrients and oxygen efficiently. By supporting these foundational systems, we help create the optimal conditions for overall cognitive support*.

At Axolt, we crafted our brain health supplement with this systemic and holistic approach in mind. Our science-based formula is designed to support the body’s natural processes involved in cognitive health*. Here's how we approached each crucial element of brain health:

The Gut-Brain Axis: The True Foundation of Cognitive Health*

The gut-brain axis is a two-way communication network between the gut and the brain. This connection affects mood, cognition, and overall mental well-being, with the gut influencing the production of key neurotransmitters like serotonin. A well-balanced gut environment is vital for maintaining this communication system, and Axolt is designed to support it.

• L-Theanine: Known for its calming effects, L-Theanine supports relaxation by promoting alpha brain waves (4). By reducing stress, it helps alleviate gut discomfort often linked to stress, thus contributing to a balanced gut-brain axis*.
• Magnesium: This essential mineral helps regulate smooth muscle function in the intestines, promoting regular bowel movements and supporting gut health (5). It also plays a role in calming the nervous system, indirectly supporting the gut-brain axis by reducing stress-related digestive issues*.
• Fiber: Soluble fiber feeds beneficial bacteria in the gut, promoting the production of short-chain fatty acids like butyrate, which have been shown to support gut lining integrity and influence brain function (6)*.
• Polyphenols: These plant-based antioxidants help modulate the gut microbiome and reduce oxidative stress in the gut, creating a healthier environment that supports the gut-brain connection*(7).
• Vitamin B (B6, B9, B12): B vitamins are essential for neurotransmitter production. In particular, B6 helps convert tryptophan into serotonin, a key neurotransmitter produced in the gut that influences mood* (8).
• Choline: Choline helps maintain cell membrane integrity, including the gut lining (9). A healthy gut lining is crucial for preventing "leaky gut," which could disrupt the gut-brain axis*.

By supporting gut health with these ingredients, Axolt helps promote a balanced gut-brain axis, which is essential for overall cognitive wellness*.

Blood-Brain Barrier (BBB): Your Brain’s First Line of Defense*

The blood-brain barrier (BBB) is a critical line of defense for the brain, preventing harmful substances from entering while allowing essential nutrients to pass through (10). A well-functioning BBB is vital for protecting brain cells and maintaining cognitive health. Axolt contains key ingredients that support the maintenance of this protective barrier.

• Polyphenols: These powerful antioxidants help protect the BBB from oxidative damage, which can compromise its integrity (7). By neutralizing free radicals, polyphenols play a role in keeping the BBB functioning properly*.
• Rutin: A flavonoid with strong antioxidant properties, rutin supports the health of endothelial cells, which form the BBB. This contributes to maintaining the barrier's structural integrity and function* (11).
• Magnesium: Magnesium supports the relaxation of blood vessels and helps maintain the tight junctions between endothelial cells in the BBB (12). This helps protect the brain from excessive permeability, which could otherwise allow harmful substances to enter*.
• Vitamin C: Known for its role in collagen production, Vitamin C supports the structural components of the BBB, ensuring that it remains intact and effective in protecting the brain* (13.).
• Vitamin B (B6, B9, B12): These vitamins help maintain healthy homocysteine levels, which are important for cardiovascular and brain health. Elevated homocysteine can compromise the BBB, so keeping it in check supports overall brain protection (14).
• Phosphatidylserine and Choline: These compounds are involved in maintaining cell membrane health, which indirectly supports the integrity of the BBB by promoting healthy brain cell membranes*(15, 23).

Axolt’s formula helps support the natural maintenance of the BBB, contributing to the brain’s defense system and promoting long-term cognitive health*.

Blood Flow & Vascular System: Fueling Cognitive Function*

Healthy blood flow is essential for the brain to receive the oxygen and nutrients it needs to function optimally. Reduced blood flow can impair cognitive performance and lead to fatigue (16). Axolt supports circulation and vascular health with ingredients that help promote blood flow to the brain.

• L-Citrulline: This amino acid helps the body produce nitric oxide, which dilates blood vessels and improves blood flow (17). By promoting better circulation, L-Citrulline ensures that oxygen and nutrients reach the brain efficiently*.
• Polyphenols: These antioxidants help improve endothelial function, which is crucial for vascular health. By supporting the health of blood vessel walls, polyphenols help maintain smooth blood flow to the brain* (18).
• Magnesium: Magnesium relaxes blood vessels, supporting healthy blood pressure levels and promoting better circulation (12). This ensures that the brain receives the oxygen and nutrients it needs to maintain cognitive function*.
• Vitamin C: As a potent antioxidant, Vitamin C protects blood vessels from oxidative stress, which can damage the vascular system over time. By reducing this stress, Vitamin C supports long-term vascular health* (19).
• Rutin: Rutin strengthens blood vessels and supports capillary health. Over time, it helps improve circulation, ensuring that blood reaches the brain efficiently* (11).
• Vitamin B (B6, B9, B12): These B vitamins play a role in reducing homocysteine levels, which, when elevated, can impair vascular health. By maintaining healthy homocysteine levels, Vitamin B contributes to overall vascular health and brain function* (20).

Axolt supports the body’s natural ability to maintain healthy blood flow, which is essential for delivering oxygen and nutrients to the brain, contributing to cognitive function and mental clarity*.

The Glymphatic System: The Brain’s Detox Pathway*

The glymphatic system is responsible for clearing waste products from the brain, including metabolic byproducts that accumulate during the day. This system primarily functions during sleep, making restful sleep crucial for its efficiency. Axolt includes ingredients that promote sleep quality and support the body’s natural detoxification processes*.

• L-Theanine: This amino acid promotes relaxation and a calm state of mind, helping improve sleep quality. By supporting restful sleep, L-Theanine contributes to the proper functioning of the glymphatic system* (4).
• Magnesium: Magnesium is known for its ability to support muscle relaxation and promote deep sleep (21). By improving sleep quality, magnesium supports the glymphatic system’s ability to clear waste from the brain during sleep*.
• Polyphenols: These compounds help reduce oxidative stress and support a healthy inflammatory response, indirectly supporting the glymphatic system’s function by maintaining a healthy environment in the brain* (22).
• Vitamin B (B6, B12): These vitamins support overall brain health and help maintain the glymphatic system’s efficiency by promoting healthy neural and vascular function* (14, 20).
• Choline: Choline supports brain function by aiding neurotransmitter production and maintaining cell membrane integrity, both of which are essential for the brain’s natural detox processes*(23).
• Rutin: Rutin supports healthy blood flow, which is critical for the proper movement of cerebrospinal fluid through the glymphatic system. This fluid is necessary for clearing toxins from the brain*(11).

Axolt’s ingredients support restful sleep and the body’s natural detoxification processes, promoting brain health and helping maintain cognitive clarity*.

Inflammation: Supporting a Healthy Inflammatory Response*

While inflammation is a natural response to stress, chronic inflammation can negatively affect brain health. Axolt includes ingredients that help the body manage inflammation, supporting a healthy response to stress and helping protect cognitive function*.

• L-Theanine: Known for its calming effects, L-Theanine helps reduce stress, which in turn supports a healthy inflammatory response in the body and brain*(24).
• Magnesium: Magnesium plays a role in modulating the body’s inflammatory response by reducing the release of pro-inflammatory cytokines (25). This helps maintain a healthy balance in the brain and body*.
• Polyphenols: These antioxidants help neutralize free radicals, reducing oxidative stress and supporting a healthy inflammatory response. This contributes to overall brain health and cognitive wellness (7, 18, 22)*.
• Vitamin B (B6, B9, B12): B vitamins help maintain healthy homocysteine levels, which is important for managing inflammation. High homocysteine is associated with increased inflammation, so keeping it in check supports brain and vascular health* (14, 20).
• Phosphatidylserine: This compound supports cell membrane health, which can help reduce inflammatory signaling in the brain* (26).
• Rutin: Rutin helps support a healthy inflammatory response by reducing oxidative stress, which can contribute to inflammation. This supports long-term brain health*(11).

By supporting a healthy inflammatory response, Axolt helps promote overall well-being and protect cognitive function*.

Glial Cells: Supporting Brain Maintenance*

Glial cells are the brain’s caretakers, supporting neurons by providing nutrients, clearing waste, and protecting brain cells from damage. These support cells play a crucial role in maintaining a healthy brain environment, and Axolt’s formula is designed to support their function*.

• L-Theanine: L-Theanine promotes relaxation and better sleep, which is important for glial cell function. Restful sleep supports the glymphatic system, which glial cells help operate*(4).
• Magnesium: Magnesium supports glial cell function by promoting healthy calcium signaling and helping to regulate inflammatory responses*(25)
• Polyphenols: These compounds help protect glial cells from oxidative stress, supporting their ability to nourish neurons and maintain a healthy brain environment*(7).
• Phosphatidylserine: This phospholipid is essential for maintaining the structural integrity of glial cells, allowing them to function properly and support neurons*(26).
• Vitamin B (B12, folate): These vitamins support myelination, the process by which glial cells form protective sheaths around neurons, promoting efficient communication in the brain* (27).
• Rutin: Rutin helps reduce oxidative stress, protecting glial cells and supporting their role in maintaining brain health* (11).

By supporting glial cell health, Axolt helps promote a well-maintained brain environment, supporting overall cognitive health*.

Neurons, Neurogenesis, and Synaptogenesis: Strengthening Cognitive Function*

Neurons are the brain’s communication network, responsible for transmitting information between different regions. Neurogenesis (the creation of new neurons) and synaptogenesis (the formation of new synaptic connections) are essential for learning, memory, and overall cognitive flexibility. Axolt’s formula supports these processes*.

• L-Tyrosine: This amino acid supports the production of dopamine, norepinephrine, and epinephrine, neurotransmitters that are important for neuron communication and cognitive performance*(28).
• Magnesium: Magnesium helps regulate calcium signaling in neurons, promoting synaptic plasticity and supporting cognitive function (29)*.
• Polyphenols: These compounds support neurogenesis and synaptogenesis by promoting brain-derived neurotrophic factor (BDNF), which is essential for the growth of new neurons and synapses* (7).
• Vitamin B (B6, B9, B12): These vitamins help maintain healthy homocysteine levels, which is important for protecting neurons and promoting the formation of new synaptic connections*(14, 20).
• Choline: Choline is a precursor to acetylcholine, a neurotransmitter that plays a crucial role in memory and learning. By supporting acetylcholine production, choline helps maintain cognitive function*(23).
• Phosphatidylserine: This compound supports the structural integrity of neuronal membranes, promoting synaptic function and neuroplasticity, which are key for learning and memory*(26).

By supporting neurogenesis and synaptogenesis, Axolt helps maintain cognitive health and adaptability, contributing to long-term brain function*.

Neurochemicals: Regulating Mood, Memory, and Focus*

Balanced neurochemicals like dopamine, serotonin, and acetylcholine are essential for regulating mood, memory, and cognitive performance. Axolt’s formulation includes ingredients that support the body’s natural production of these key neurochemicals*.

• L-Theanine: L-Theanine promotes relaxation by supporting healthy serotonin and dopamine levels, which are critical for mood regulation and mental clarity (30)*.
• Magnesium: Magnesium supports the function of GABA, a neurotransmitter that helps reduce stress and promotes relaxation*(31).
• Choline: Choline is a precursor to acetylcholine, which plays a key role in memory and learning* (23).
• Vitamin C: This antioxidant helps in the synthesis of dopamine, supporting overall brain function and cognitive health*(19).
• Vitamin B (B6, B9, B12): These vitamins support the synthesis of neurotransmitters like serotonin and dopamine, promoting mood balance and cognitive function*(14, 20).
• Rutin: Rutin supports dopamine pathways, helping maintain brain function and supporting overall cognitive health*(11).

By supporting neurochemical balance, Axolt promotes mental clarity, emotional well-being, and cognitive function*.

A Holistic, Science-Based Formula for Long-Term Brain Health*

Axolt was crafted with a singular goal in mind: to provide a comprehensive brain health solution that supports both immediate cognitive performance and long-term brain vitality. By addressing each layer of brain health—gut-brain interaction, neurogenesis, vascular health, and more—Axolt offers a science-backed formula that supports your brain’s essential systems for peak mental performance today and lasting cognitive protection for the future.

With every carefully chosen ingredient, we ensure that Axolt not only enhances your current mental clarity and focus but also works to protect and boost your brain's long-term health. Whether you're looking to improve memory, reduce stress, or increase your mental stamina, Axolt delivers a complete brain health solution that fits seamlessly into your daily routine.

Your journey to a healthier and sharper brain starts today. Order Axolt today.

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